KMID : 0617320020110010318
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Journal of Pharmacetical Sceiences Ewha Womans University 2002 Volume.11 No. 1 p.318 ~ p.320
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Stereoselective synthesis of amino-substituted apio dideoxynucleosides through a distant neighboring group effect
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Choi, Won Jun
Ahn, Hee Sung/Kim, Hea Ok/Kim, Sanghee/Chun, Moon Woo/Jeong, Lak Shin
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Abstract
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Novel amino-substituted apio nucleoside (2R, 4R)-LJ-45 as a potential anti-HBV agent was steroselectively synthesized from the known oxazolidine 1 through a distant neighboring group effect. It is believed that this synthetic method using a chiral template, (-)-L-serine methyl ester can be generally applied to the synthesis of other chiral amino-substituted nucleosides.
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